Description
CD-349 is a calcium channel antagonist potentially for the treatment of angina pectoris and hypertension. CD-349 inhibited the noradrenaline (NA)-induced contraction of aortas in Ca2(+)-free medium. The blocking effect of CD349 on neuronal Ca2+ influx, in combination with a cerebral vasodilatory action, may contribute to a favorable effect on ischemic brain damage.
Uses
CD-349 is an active compound.
References
[1] Inhibition of adenosine 3′, 5′-cyclic monophosphate phosphodiesterase by CD-349, a novel 1, 4-dihydropyridine derivative: effect of EGTA on the inhibitory activity
