Add 4743 is an analog of ciglitazone; adipogenic agent.
Uses
AD 4743 (ADD 4743) is a metabolite of Ciglitazone (HY-W011220). AD 4743 is an adipogenic agent. AD 4743 induces FPRP accumulation and accumulation of lipid droplets. AD 4743 inhibits cell proliferation of preadipose cells[1][2].
References
[1] Orlicky DJ, et al. Synthesis and accumulation of a receptor regulatory protein associated with lipid droplet accumulation in 3T3-L1 cells. J Lipid Res. 1998 Jun;39(6):1152-61. PMID:9643346 [2] Hiragun A, et al. Preadipocyte differentiation in vitro: identification of a highly active adipogenic agent. J Cell Physiol. 1988 Jan;134(1):124-30. DOI:10.1002/jcp.1041340115
