Sigmoidin B, a prenylated flavanone, is a selective 5-lipoxygenase inhibitor. Sigmoidin B is a potent scavenger of the DPPH radical. Sigmoidin B has antigenotoxic activity that inhibits genotoxicity induced by Aflatoxin B1 (HY-N6615), with an IC50 of 18.7 μg/mL. Sigmoidin B has anti-inflammatory activity and antioxidant properties[1][2].
Definition
ChEBI: A tetrahydroxyflavanone that is (2S)-flavanone substituted by hydroxy groups at positions 5, 7, 3' and 4' and a prenyl group at position 5'. Isolated from Erythrina sigmoidea, it exhibits anti-inflammatory and antioxidant acti
ities.
in vivo
In the assay of phospholipase A2-induced mouse paw oedema, Sigmoidin B (5 mg/kg, ip) inhibits oedema formation at 60 min. In the Phorbol 12-myristate 13-acetate (PMA) (HY-18739) test, Sigmoidin B decreases the induced oedema by 83%[1].
IC 50
5-Lipoxygenase
References
[1] Njamen D, et al. Anti-inflammatory activities of two flavanones, sigmoidin A and sigmoidin B, from Erythrina sigmoidea. Planta Med. 2004 Feb;70(2):104-7. DOI:10.1055/s-2004-815484 [2] Zarev Y, et al. Antigenotoxic prenylated flavonoids from stem bark of Erythrina latissima. Phytochemistry. 2017 Sep;141:140-146. DOI:10.1016/j.phytochem.2017.06.003
