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Heart-homing peptide is a peptide, CRPPR. CRPPR is a linear peptide containing arginine that has been identified as a heart-homing peptide owing to its ability to specifically bind to heart endothelium, and cysteine-rich protein-2 (CRIP-2) has been proposed as the receptor. Heart-homing peptide can be used for conjugating liposomes[1][2].

[1] Zhang H, et al. The cargo of CRPPR-conjugated liposomes crosses the intact murine cardiac endothelium. J Control Release. 2012 Oct 10;163(1):10-7. DOI:10.1016/j.jconrel.2012.06.038
[2] Rodríguez-Castejón J, et al. Targeting strategies with lipid vectors for nucleic acid supplementation therapy in Fabry disease: a systematic review. Drug Deliv Transl Res. 2024 Apr 8. DOI:10.1007/s13346-024-01583-0