874745-43-4

Cannabinoid agonists are typically highly lipophilic compounds that require solubilization with either a surfactant agent or adherence to a water miscible substance such as albumin, Tween 80, or Emulphor. O-2545 is a potent water-soluble agonist of central cannabinoid (CB₁) and peripheral cannabinoid (CB₂) receptors with K_i values of 1.5 and 0.32 nM, respectively.¹ When dissolved in saline, O-2545 was highly efficacious in mouse behavioral models when administered either intravenously or intracerebroventricularly.¹

O-2545 hydrochloride is a highly potent, water-soluble CB1/CB2 receptor agonist (with Ki values of 1.5 and 0.32 nM for CB1 and CB2 respectively), can be used for epilepsy, pain, multiple sclerosis research[1].

1. Martin, B.R., Wiley, J.L., Beletskaya, I., et al. Pharmacological characterization of novel water-soluble cannabinoids J. Pharmacol. Exp. Ther. 318,1230-1239(2006).