870223-96-4

AMG-Tie2-1 is an inhibitor of tunica interna endothelial cell kinase 2 (Tie2) and VEGF receptor 2 (VEGFR2) with IC₅₀ values of 1 and 3 nM, respectively, in a homogenous time-resolved fluorescence (HTRF) assay. It inhibits angiopoietin 1-induced Tie2 autophosphorylation in EA.hy926 human endothelial cells (IC₅₀ = 10 nM).

AMG-Tie 2-1 is a pyridinyltriazine Tie-2 kinase inhibitor. A useful research chemical for cancer metabolism research studies.

Store at -20°C

[1] BRIAN L. HODOUS. Evolution of a Highly Selective and Potent 2-(Pyridin-2-yl)-1,3,5-triazine Tie-2 Kinase Inhibitor[J]. Journal of Medicinal Chemistry, 2007, 50 4: 611-626. DOI: 10.1021/jm061107l