86933-99-5

Name	vanoxonin
CAS	86933-99-5
Molecular Formula	C18H25N3O9
MDL Number	MFCD01939818
Molecular Weight	427.408
MOL File	86933-99-5.mol

Synonyms

vanoxonin MG-245-CF2-A Antibitic MG-245CF2A Antibiotic MG 245CF2A (+)-N-(2,3-Dihydroxybenzoyl)-L-Thr-N5-Ac-N5-hydroxy-L-Orn-OH N5-Acetyl-N2-[N-(2,3-dihydroxybenzoyl)-L-threonyl]-N5-hydroxy-L-ornithine

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Chemical Properties

density	1.460±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
storage temp.	-20°C
form	A solid
pka	3.265±0.10(predicted)

Hazard Information

Uses

Vanoxonin is an inhibitor of thymidylate synthase found in Saccharopolyspora hirsuta with an IC50 value of 0.7 μg/mL[1].

Biological Activity

Vanoxonin is a bacterial metabolite that has been found in S. hirsuta.1 It forms a complex with vanadium, and the complex inhibits thymidylate synthetase with an IC50 value of 0.7 μg/ml. The vanoxonin-vanadium complex is cytotoxic to L1210 leukemia cells (MIC = 25 μg/ml) and increases survival in Ehrlich murine spontaneous adenocarcinoma and L1210 mouse tumor models.

storage

-20°C

References

1.Kanai, F., Sawa, T., Hamada, M., et al.Vanoxonin, a new inhibitor of thymidylate synthetaseJ. Antibiot. (Tokyo)36(6)656-660(1983)

Supplier

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Telephone 18818260767

Websitehttp://www.chemegen.com

Beijing Biocreative Technology Co., Ltd.

Telephone 15522676233

Websitehttp://www.bestbaiao.com/

Shanghai Yifei Biotechnology Co. , Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

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178182-49-5 173046-02-1

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