86690-14-4

Halenaquinone is a phosphatidylinositol 3-kinase inhibitor and can be isolated from the marine sponge Petrosia alfiani. Halenaquinone inhibits RANKL-induced osteoclastogenesis, and induces cell apoptosis in PC12 cells[1][2][3].

[1] Deborah M. Roll, et al. Halenaquinone, a pentacyclic polyketide from a marine sponge. ：Journal of the American Chemical Society.Vol 105/Issue 19.
[2] Tsukamoto S, et al. Halenaquinone inhibits RANKL-induced osteoclastogenesis. Bioorg Med Chem Lett. 2014;24(22):5315-5317. DOI:10.1016/j.bmcl.2014.09.043
[3] Fujiwara H, et al. Halenaquinone, a novel phosphatidylinositol 3-kinase inhibitor from a marine sponge, induces apoptosis in PC12 cells. Eur J Pharmacol. 2001;413(1):37-45. DOI:10.1016/s0014-2999(00)00944-4