866021-48-9
| Name | Unii-p9vxv1408y |
| CAS | 866021-48-9 |
| MDL Number | MFCD19443689 |
Synonyms
4-[2-[[(6R
Ceftaroline
Unii-p9vxv1408y
Ceftarolin Fosamil
Ceftaroline Impurity8
Ceftaroline USP/EP/BP
Unii-p9vxv1408y USP/EP/BP
Ceftaroline Fosamil Acetate Hydrate
7R)-2-Carboxy-7-[[(2Z)-(ethoxyimino)[5-(phosphonoamino)-1
acetic acid,(6R,7R)-7-[[(2Z)-2-ethoxyimino-2-[5-(phosphonoamino)
4-thiadiazol-3-yl]acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]thio]-4-thiazolyl]-1-methylpyridinium acetate hydrate
acetic acid,(6R,7R)-7-[[(2Z)-2-ethoxyimino-2-[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetyl]amino]-3-[[4-(1-methylpyridin-1-ium-4-yl)-1,3-thiazol-2-yl]sulfanyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate,hydrate
Hazard Information
Definition
ChEBI: Ceftaroline fosamil acetate monohydrate is a hydrate that is the monohydrate form of ceftaroline fosamil acetate. A prodrug for ceftaroline, used for the treatment of adults with acute bacterial skin and skin structure infections. It has a role as an antimicrobial agent, an antibacterial drug and a prodrug. It contains a ceftaroline fosamil acetate.
Antimicrobial activity
A semisynthetic cephalosporin formulated as the water-soluble
fosamil acetate prodrug for intravenous administration.
Its properties are similar to those of ceftobiprole, with
which it shares an enhanced affinity for penicillin-binding
protein 2′ (2a) of methicillin-resistant Staph. aureus.
It is hydrolyzed by extended-spectrum β-lactamases and is not active against Amp-C derepressed strains of Gram-negative
bacilli.
Pharmacokinetics
Cmax 600 mg intravenous (1-h infusion): 19 mg/L end infusion
Plasma half-life: 2.6 h
Volume of distribution: 0.37 L/kg
Plasma protein binding :<20%
Like ceftobiprole, ceftaroline fosamil is rapidly hydrolyzed in plasma after intravenous infusion and excreted principally in urine. In preliminary clinical studies it appears to be well tolerated.
Plasma half-life: 2.6 h
Volume of distribution: 0.37 L/kg
Plasma protein binding :<20%
Like ceftobiprole, ceftaroline fosamil is rapidly hydrolyzed in plasma after intravenous infusion and excreted principally in urine. In preliminary clinical studies it appears to be well tolerated.
Questions And Answer
-
Application
1) Acute bacterial skin and skin structure infections (ABSSSI): This product is indicated for ABSSSI caused by susceptible strains of Gram-positive and Gram-negative bacteria, including Staphylococcus aureus (including methicillin-resistant and methicillin-sensitive isolates), Streptococcus pyogenes, Streptococcus agalactiae, Escherichia coli, Klebsiella pneumoniae, and Klebsiella oxytocinum. 2) Community-acquired bacterial pneumonia (CABP): This product is indicated for CABP caused by susceptible strains of Gram-positive and Gram-negative bacteria, including Streptococcus pneumoniae (including patients with bacteremia), Staphylococcus aureus (methicillin-sensitive isolates), Haemophilus influenzae, Klebsiella pneumoniae, Klebsiella oxytocinum, and Escherichia coli.;
Supplier
Yield Pharmaceutical Techonlogy (Suzhou) Co.,Ltd.
Telephone 13382188332
Websitehttp://www.yieldpharm.com
Hubei Hicks Biochemical Co., Ltd
Telephone17362916295; 17362916295
Websitehttps://www.hkssh.com
Hubei Chenxin Pharmaceutical Co., Ltd.
Telephone 18696113233
Websitehttp://www.chenxinyaoye.cn
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Telephone0731-85526065 13308475853
Websitehttp://www.hnhbsj.com/
Nanjing Sunlida Biological Technology Co., Ltd.
Telephone025-57798810 18652991625
Website
Conier Chem & Pharma Co.,Ltd,
Telephone023-62879767
Websitehttp://www.conier.com/
Shandong Boluoda Biological Technology Co., Ltd.
Telephone0531-68651502
Websitehttp://boluoda.com/indel.html
Hangzhou J&H Chemical Co., Ltd.
Telephone0571-87396432
Websitehttp://www.jhechem.com
Wuhan Bo-Sen Biological Technology Co., Ltd
Telephone027-51335350 15107175693
Websitehttp://www.bosenyuan.com
Shanghai QianYan Bio-technology Co., Ltd
Telephone02781293128
Websitehttps://www.chemicalbook.com/ShowSupplierProductsList19348/0_EN.htm
Raw material medicin reagent co.,Ltd
Telephone
Websitehttp://www.njromanme.com
Hubei widely chemical technology Co., Ltd.
Telephone027-83991130 18627774460
Websitehttp://www.widelychemical.com
Suzhou Ryway Biotech Co., Ltd
Telephone180-1316-0973
Websitehttp://www.rywaybio.com
Wellman Pharmaceutical Group Limited
Telephone15807197853 18971451745
Websitehttps://www.4008081911.com
Shijiazhuang Als Pharmaceutical Technology Co., Ltd.
Telephone0311-85150550 18932901920
Websitehttp://www.alspharm.com
Hubei XinMingTai Chemical Co., Ltd.
Telephone177-7179-1433 17771741533
Websitehttps://www.chemicalbook.com/supplier/10010892/
Rhawn Reagent
Telephone400-400-1332688 18019345275
Websitehttp://www.rhawn.cn
Shenzhen Barker Chemical Technology Co., Ltd.
Telephone18825257575
Websitehttps://www.chemicalbook.com/ShowSupplierProductsList30531/0_EN.htm
1of4
PROMPT×
PROMPT
The What'sApp is temporarily not supported in mainland China
The What'sApp is temporarily not supported in mainland China
Cancel
Determine