Enzyme inhibitor
This fluoroquinolone-class antibiotic (FW = 334.31 g/mol; CAS 86393-37-
5) is a broad-spectrum systemic agent that targets Type II DNA
topoisomerases (gyrases) required for bacterial replication and transcription
. Ninety percent of Escherichia coli, Klebsiella species, Aeromonas,
Salmonella, Shigella, Citrobacter, Enterobacter species, Proteus mirabilis,
Serratia marcescens, and Morganella morganii were inhibited by ≤ 0.5
μg/mL. Amifloxacin inhibited Branhamella, Haemophilus, and
Neisseria at ≤ 0.25 μg/mL, and 90% of Pseudomonas aeruginosa,
including gentamicin and carbenicillin-resistant isolates, at 4 ≤g/mL. It
also inhibited Staphylococci, including methicillin-resistant isolates, but
was less active against Streptococci and Bacteroides species. For
mechanism of action, see Ciprofloxacin, which is the prototypical member
of this antibiotic class.
