Description
Lenampicillin hydrochloride is
improved bioavailability.
Chemical Properties
Lenampicillin Hydrochloride: C????H????N??O??S·HCl, [80734-02-7]. White to pale yellowish-white powder with a peculiar odor and a bitter taste. Very soluble in water, freely soluble in methanol and ethanol, and practically insoluble in ether. Melting point: 145°C (decomposition). Acute toxicity LD50 in male and female rats, male and female mice (mg/kg): approximately 10,000, approximately 10,000, 8294, 8492 oral; 4362, 4471, 3576, 4284 subcutaneous; 876, 838, 711, 775 intravenous. Acute toxicity LD50 in dogs (mg/kg): >300 oral.
Originator
Kanebo (Japan)
Uses
LENAMPICILLIN is semi-synthetic penicillins and prodrugs of ampicillin, but are 2-4 times more potent. They can be taken orally, are well absorbed, and have a high efficacy rate. Their uses are similar to ampicillin, and they can be used as a substitute. They are used for acute bronchitis, pneumonia, lung abscess, pharyngitis, superficial secondary infections of traumatic and surgical wounds, periodontitis, otitis media, etc.
Definition
ChEBI: Lenampicillin is a penicillanic acid ester that is the (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester of ampicillin. It is a prodrug of ampicillin. It has a role as a prodrug. It is a penicillanic acid ester and a ketene acetal. It is functionally related to an ampicillin.
Brand name
Varacillin;
Takacillin
