858275-30-6

b) Synthesis of 2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde 2-Methyl-7-azaindole (835 mg) was dissolved in a solvent mixture of 5.3 mL of water and 1.6 mL of ethyl acetate, followed by the addition of 1.32 g of urotropine (1,3,5,7-tetraazatricyclo[3.3.1.1^3,7]decane). The reaction mixture was reacted according to the conditions described in Example 2. Upon completion of the reaction, 580 mg of a mixture containing 60% 2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde was obtained, the product being a beige solid. The identification data of 2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde is given below: LC/MS (1): retention time: 1.7 minutes Mass spectrum (1): (ES+): m/z = 161 [MH+]

[1] Bioorganic and Medicinal Chemistry, 2007, vol. 15, # 21, p. 6782 - 6795
[2] Patent: US2009/253679, 2009, A1. Location in patent: Page/Page column 37