Description
(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one is the side chain of ivabradine hydrochloride. Ivabradine and its medicinal salts, especially its hydrochloride, have very important pharmacological and therapeutic properties, especially, in slowing down the heart rate. Relating compounds can be used to treat or prevent various clinical myocardial ischemia conditions, such as angina pectoris, myocardial infarction and related rhythm disorders, various pathologies involving rhythm disorders, especially supraventricular rhythm disorders.
References
[1] Patent: WO2014/102827, 2014, A1. Location in patent: Paragraph 0120
[2] Patent: US4490369, 1984, A
[3] Archiv der Pharmazie, 2010, vol. 343, # 2, p. 114 - 119
[4] Journal of Medicinal Chemistry, 1990, vol. 33, # 5, p. 1496 - 1504
[5] Patent: WO2010/72409, 2010, A1. Location in patent: Page/Page column 18-19
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