ChemicalBook CAS DataBase List 851518-71-3

851518-71-3

Name	N-(4-HYDROXYPHENYL)-5-METHYL-2-1H-PYRIDONE
CAS	851518-71-3
Molecular Formula	C12H11NO2
MDL Number	MFCD07369446
Molecular Weight	201.22
MOL File	851518-71-3.mol

Chemical Properties

Appearance	White Solid
Melting point	161-162°C
Boiling point	416.0±37.0 °C(Predicted)
density	1.248±0.06 g/cm3(Predicted)
storage temp.	-20?C Freezer
solubility	Chloroform (Slightly), Methanol
form	Solid
pka	10.08±0.30(Predicted)
color	White to Off-White

Hazard Information

Spectrum Detail

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Animal Model:	Five-week-old male C57BL/6J mice (intraperitoneally injected with 10% carbon tetrachloride (CCl₄) in corn oil at 5?μL/g of body weight, three times per week, for 6?weeks; or fed a diet containing 1% 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) for 4?weeks)^[1]
Dosage:	50, 100 mg/kg
Administration:	Oral gavage (p.o.)
Result:	The levels of hepatic inflammatory infiltration were improved. Significantly reduced the collagen fibre content. Decreased the hepatic hydroxyproline content. Significantly reduced the mRNA levels of fibrosis-related genes, including Acta2, Col1a1, Col3a1, Mmp9 and Timp1. Reduced the levels of α-SMA and collagen 1 (Col1) in liver tissues. Upregulated Smad7 protein expression.

851518-71-3

Chemical Properties

Hazard Information

Chemical Properties

Uses

in vivo

Spectrum Detail

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