ChemicalBook CAS DataBase List 85-34-7

85-34-7

Name	CHLORFENAC
CAS	85-34-7
EINECS(EC#)	201-599-3
Molecular Formula	C8H5Cl3O2
MDL Number	MFCD00014367
Molecular Weight	239.48
MOL File	85-34-7.mol

Chemical Properties

Melting point	161 °C
Boiling point	341.55°C (rough estimate)
density	1.568
refractive index	1.4521 (estimate)
storage temp.	0-6°C
form	neat
pka	3.63±0.10(Predicted)
color	Colorless crystals
Water Solubility	0.2g/L(28 ºC)
Merck	13,2103
BRN	2113332
Henry's Law Constant	8.3×10^-1 mol/(m³Pa) at 25℃, Mackay et al. (2006)
EPA Substance Registry System	Chlorfenac (85-34-7)

Safety Data

Hazard Codes	N-Xn,N,Xn
Risk Statements	51/53-22 less more
Safety Statements	61-36-45-26 less more
RIDADR	3077
WGK Germany	2
RTECS	AJ8750000
TSCA	TSCA listed
HS Code	29163990
Hazardous Substances Data	85-34-7(Hazardous Substances Data)
Toxicity	LD50 orally in rats: 3000 mg/kg (Bailey, White) less more

Hazard Information

Description

Chlorfenac is an obsolete herbicide for the control of annual weeds and grasses. It has a low aqueous solubility and is highly volatile. It may be persistent in both soil and water systems. It is moderately toxic to aquatic fife but has a low toxicity to birds. It is moderately toxic to mammals if ingested.

Uses

Chlorfenac is a herbicide used in agriculture for weed control mainly in sugar canes as well as other crops.

Uses

Herbicide.

Definition

ChEBI: Chlorfenac is a member of the class of phenylacetic acids that is phenylacetic acid in which the phenyl group has been substituted by chlorines at positions 2, 3, and 6. An obsolete herbicide that was used as its sodium and ammonium salts. It has a role as a herbicide, an agrochemical and a synthetic auxin. It is a trichlorobenzene and a member of phenylacetic acids. It is a conjugate acid of a chlorfenac(1-).

Production Methods

Chlorfenac was commercially produced via a process that began with the preparation of 2-chloro-4-fluorophenol through selective chlorination of para-fluorophenol using chlorine gas or N-chlorosuccinimide in acetic acid, followed by deprotonation with sodium hydroxide to form the phenoxide salt. The key ether linkage was formed via nucleophilic substitution of ethyl chloroacetate with the phenoxide in ethanol at reflux, yielding the ethyl ester intermediate. Saponification with sodium hydroxide in aqueous methanol at 60–80°C, followed by acidification with hydrochloric acid, provided chlorfenac as the free acid.

Mechanism of action

Inhibits cell wall synthesis, Systemic, absorbed predominately by plant roots, with translocation. Auxin mimic.

Safety Profile

Moderately toxic by ingestion andskin contact. When heated to decomposition it emits toxicfumes of Clí. An herbicide used for preemergence seasonlongcontrol of weeds.

Pesticide Type

Herbicide

Supplier

J & K SCIENTIFIC LTD.

Telephone18210857532 18210857532

Websitehttps://www.jkchemical.com

Chemsky (shanghai) International Co.,Ltd

Telephone021-50135380

Websitehttp://www.shchemsky.com

Sichuan Kulinan Technology Co., Ltd

Telephone400-1166-196 18981987031

Websitehttp://www.hx-r.com/

Chengdu Ai Keda Chemical Technology Co., Ltd.

Telephone4008-755-333 18080918076

Websitehttp://www.aikeshiji.com

Alta Scientific Co., Ltd.

Telephone022-6537-8550 15522853686

Websitehttp://www.altascientific.cn

Shanghai Xilong Biochemical Technology Co., Ltd.

Telephone021-52907766-8042

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList19329/0_EN.htm

Shenzhen Regent Biochemical Technology Co., Ltd.

Telephone0755-85201366 18938635012

Websitehttp://www.regentsciences.com/

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Telephone+86-400-002-6226

Websitehttps://www.rrkchem.com

Shanghai Jiegu Biotechnology Co., Ltd.

Telephone021-51698675

Websitehttp://www.jiejiegroup.com

CONIER CHEM AND PHARMA LIMITED

Telephone

Websitehttp://www.conier.com/

Birdo (Shanghai) Medical Technology Co., Ltd.

Telephone021-58099077-8041 18601625411

Websitehttps://product.birdotech.com/

Energy Chemical

Telephone021-58432009 400-005-6266

Websitehttp://www.energy-chemical.com

Xi'an Zhenghao Biotechnology Co., Ltd

Telephone 19829389091

Websitehttps://www.chemicalbook.com/supplier/23951237/

TCI (Shanghai) Chemical Trading Co., Ltd.

Telephone021-61109150

Websitehttps://www.tcisct.com

Hebei Dueling International Trade Co. LTD

Telephone 18032116176

Websitehttps://www.dulingchem.com/

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

HANGZHOU LEAP CHEM CO., LTD.

Telephone+86-571-87711850 +86-15355479329

Websitehttp://www.leapchem.com

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