ChemicalBook CAS DataBase List 849550-67-0

849550-67-0

Chemical Properties

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Animal Model:	Athymic nu/nu female mice implanted s.c. in the flank with 1×10⁷ LoVo human colon adenocarcinoma cells^[1].
Dosage:	5, 10, 15, and 20 mg/kg
Administration:	I.V. injection every 4 days for 4 cycles.
Result:	The compound showed dose-dependent effects, with good antitumor activity at 20 and 15 mg/kg.

Animal Model:	Athymic nu/nu female mice implanted s.c. in the flank with 1×10⁶ U87-MG human glioblastoma cells^[1].
Dosage:	25 mg/kg.
Administration:	P.O. or I.V. on days 0, 7, 14.
Result:	The compound was active by p.o. or i.v. administration against human tumor xenografts.