849061-97-8

Yellow crystalline powder

Quercetin is an abundant flavonoid that has been isolated from a variety of fruits and vegetables and has diverse biological activities, including antioxidant, anticancer, and anti-inflammatory properties. Quercetin (5-100 mg/kg) reduces autophagy, decreases the levels of reactive oxygen species (ROS) and malondialdehyde (MDA) content, and increases total antioxidant capacity in the kidney in a mouse model of cadmium-induced autophagy. It reduces tumor growth, induces apoptosis, and halts the cell cycle at the G₁ phase in an HL60 mouse xenograft model when administered at a dose of 120 mg/kg every four days. Quercetin (30 μM) also inhibits histamine release from antigen-stimulated RBL-2H3 cells and decreases the expression of TNF-α, IL-1β, IL-6, and IL-8 induced by PMACI in HMC-1 cells.

Quercetin hydrate was used as leishmanicidal flavonol to investigate the inhibition of recombinant arginase from Leishmania amazonensis by quercetin, quercitrin and isoquercitrin.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Quercetin may be used as a pharmaceutical reference standard for the analysis of the analyte in biological samples and pharmaceutical formulations by high performance liquid chromatography (HPLC) and spectrophotometric methods.

Quercetin is a flavanol with strong antioxidant property. Due to the ability to scavenge free radicals and bind transition metal ions, quercetin is commonly used as a nutritional supplement and physiochemical remedy for a large number of diseases.

[1] ANDRANA KARLA CALGAROTTO. Antitumor activities of Quercetin and Green Tea in xenografts of human leukemia HL60 cells.[J]. Scientific Reports, 2018: 3459. DOI: 10.1038/s41598-018-21516-5
[2] YUAN YUAN. Quercetin inhibited cadmium-induced autophagy in the mouse kidney via inhibition of oxidative stress[J]. Journal of Toxicologic Pathology, 2016, 29 1: 247-252. DOI: 10.1293/tox.2016-0026
[3] HYO-HYUN PARK. Flavonoids inhibit histamine release and expression of proinflammatory cytokines in mast cells[J]. Archives of Pharmacal Research, 2008, 31 10: 1303-1311. DOI: 10.1007/s12272-001-2110-5
[4] LAURA MARíN. De novo biosynthesis of garbanzol and fustin in Streptomyces albus based on a potential flavanone 3-hydroxylase with 2-hydroxylase side activity[J]. Microbial Biotechnology, 2021, 14 5: 2009-2024. DOI: 10.1111/1751-7915.13874