848-75-9

Name	LORMETAZEPAM
CAS	848-75-9
EINECS(EC#)	212-700-5
Molecular Formula	C16H12Cl2N2O2
MDL Number	MFCD00058578
Molecular Weight	335.18
MOL File	848-75-9.mol

Synonyms

Loramet WY-4082 Noctamid Ergocalm RO 5-5516 LORMETAZEPAM lormethazepam METHYLLORAZEPAM N-Methyllorazepam (RS)-Lormetazepam Lormetazepam solution LORMETAZEPAM USP/EP/BP Lormetazepam Solution, 100ppm LORMETAZEPAM METHANOL SOLUTION 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-3H-1,4-benzodiazepin-2-one 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-2,3-dihydro-1h-1,4-benzodiaze 2h-1,4-benzodiazepin-2-one,7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy 2h-1,4-benzodiazepin-2-one,1,3-dihydro-7-chloro-5-(o-chlorophenyl)-3-hydroxy-1 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one 7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one 7-Chloro-1,3-dihydro-5-(o-chlorophenyl)-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-(o-chlorophenyl)-3-hydroxy-1-methyl- 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl- 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl- (9CI) 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl- (7CI, 8CI)

Chemical Properties

Melting point	163-168°C
Boiling point	575.8±50.0 °C(Predicted)
density	1.4463 (rough estimate)
refractive index	1.6100 (estimate)
Fp	9℃
storage temp.	Controlled Substance, -20°C Freezer
pka	11.60±0.40(Predicted)

Safety Data

Hazard Codes	F,T
Risk Statements	11-23/24/25-39/23/24/25-22 less more
Safety Statements	7-16-36/37-45-36 less more
RIDADR	3249
WGK Germany	1
HazardClass	6.1(b)
PackingGroup	III

Hazard Information

Chemical Properties

Pale Green Solid

Originator

Loramet ,Wyeth, W. Germany,1980

Uses

An analog of Lorazepam (L469850). Sedative, hypnotic. Controlled substance (depressant).

Definition

ChEBI: Lormetazepam is a 1,4-benzodiazepinone compound having a methyl substituent at the 1-position, a hydroxy substituent at the 3-position, a 2-chlorophenyl group at the 5-position and a chloro substituent at the 7-position. It has a role as a sedative. It is a 1,4-benzodiazepinone and an organochlorine compound.

Manufacturing Process

To a suspension of 3.4 g of 3-acetoxy-7-chloro-1,3-dihydro-5-(ochlorophenyl)-2H-1,4-benzodiazepin-2-one in 80 ml of alcohol was added 6 ml of 4 N sodium hydroxide. After complete solution had taken place a solid precipitated that redissolved upon the addition of 80 ml of water. The solution was acidified with acetic acid to give white crystals. After recrystallization from alcohol the compound melted at 192°C to 194°C.

Therapeutic Function

Hypnotic

Clinical Use

#N/A

Drug interactions

Potentially hazardous interactions with other drugs Antibacterials: metabolism possibly increased by rifampicin. Antipsychotics: increased sedative effects; risk of serious adverse effects in combination with clozapine. Antivirals: concentration possibly increased by ritonavir. Disulfiram: metabolism inhibited, increased sedative effects. Sodium oxybate: enhanced effect - avoid.

Metabolism

Lormetazepam is metabolised in the liver to the inactive glucuronide, and excreted in the urine.

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