845861-39-4

CP 94,253 is an agonist of the serotonin (5-HT) receptor subtype 5-HT_1B (K_i = 2 nM in a radioligand binding assay). It is selective for 5-HT_1B over 5-HT_1A, 5-HT_1D, 5-HT_1C, and 5-HT₂ receptors (K_is = 89, 49, 860, and 1,600 nM, respectively). CP 94,253 (10 and 17 mg/kg) reduces aggressive behavior in a resident-intruder test in mice, as well as decreases alcohol-induced aggression in mice with an ED₅₀ value of 3.8 mg/kg. It decreases the time mice spend immobile in the forced swim test by 43%, indicating antidepressant-like activity, when administered at a dose of 5 mg/kg. CP 94,253 (2.5 mg/kg) also increases drinking in the Vogel punished drinking task, indicating anxiolytic-like activity, in rats.

CP 94253 Hydrochloride is a potent and selective serotonin 5-HT1B receptor agonist with anticonvulsant activity.

Desiccate at RT

[1] DR. B. KENNETH KOE. Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253[J]. Drug Development Research, 1992, 26 3: 241-250. DOI: 10.1002/ddr.430260305
[2] E W FISH  K A M  S Faccidomo. Aggression heightened by alcohol or social instigation in mice: reduction by the 5-HT(1B) receptor agonist CP-94,253.[J]. Psychopharmacology, 1999, 146 4: 391-399. DOI: 10.1007/pl00005484
[3] EWA TATARCZY?SKA. Antidepressant-like effect of the selective 5-HT1B receptor agonist CP 94253: A possible mechanism of action[J]. European journal of pharmacology, 2005, 516 1: Pages 46-50. DOI: 10.1016/j.ejphar.2005.04.025
[4] EWA CHOJNACKA-WóJCIK  Ewa T  Aleksandra K?odzińska. The anxiolytic-like effect of 5-HT1B receptor ligands in rats: a possible mechanism of action[J]. Journal of Pharmacy and Pharmacology, 2010, 57 2: 253-257. DOI: 10.1211/0022357055399