84540-64-7

Name	TRIS SUCCINATE
CAS	84540-64-7
EINECS(EC#)	283-159-0
Molecular Formula	C12H28N2O10
MDL Number	MFCD00058327
Molecular Weight	360.36
MOL File	84540-64-7.mol

Synonyms

TRIS SUCCINATE TRIZMA SUCCINATE TRIS-SUCCINATE 99% Tris-succinate,99% TRIS(HYDROXYMETHYL)AMINOMETHANE SUCCINATE DI[TRIS(HYDROXYMETHYL)AMINOMETHANE] SUCCINATE Tris(hydroxymethyl)aminomethane succinate >98% 2-AMINO-2-(HYDROXYMETHYL)-1,3-PROPANEDIOL SUCCINATE succinic acid, compound with 2-amino-2-(hydroxymethyl)propane-1,3-diol (1:1)

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Chemical Properties

Appearance	White granular or crystalline powder
Melting point	138-141 °C

Safety Data

Safety Statements	24/25 less more
HS Code	2921490090

Hazard Information

Chemical Properties

White granular or crystalline powder

Uses

Succinic acid tromethamine is a potent and orally active anxiolytic agent. Succinic acid tromethamine is an intermediate product of the tricarboxylic acid cycle. Succinic acid tromethamine can be used as a precursor of many industrially important chemicals in food, chemical and pharmaceutical industries[1][2][3].

in vivo

Succinic acid tromethamine (3, 6 mg/kg; p.o.) increases the percentage of entries into open arms and of time spent on open arms in male mice^[3].
Succinic acid tromethamine (3, 6, 12 mg/kg; i.p.) significant increases in food intake during 5 min, and 40 min after drug administration rectal temperature was measured, succinic acid at a dose of 1.5 mg/kg, inhibited stress-induced hyperthermia^[3].

IC 50

Microbial Metabolite; Human Endogenous Metabolite

References

[1] Zhang YJ, et al. Optimization of succinic acid fermentation with Actinobacillus succinogenes by response surface methodology (RSM). J Zhejiang Univ Sci B. 2012 Feb;13(2):103-10. DOI:10.1631/jzus.B1100134
[2] A T JOHNS, et al. The production of propionic acid by decarboxylation of succinic acid in a bacterial fermentation. Biochem J. 1948;42(1):ii. PMID:18934530
[3] Si Wei Chen, Anxiolytic-like effect of succinic acid in mice. Life Sci. 2003 Nov 7;73(25):3257-64. DOI:10.1016/j.lfs.2003.06.017

Supplier

Spectrum Chemical Manufacturing Corp.

Telephone021-021-021-67601398-809-809-809 15221380277

Websitehttps://www.spectrumchemical.com/OA_HTML/index.jsp?minisite=10020&respid=22372&language=US

Career Henan Chemica Co

Telephone+86-0371-86658258 +86-13203830695

Websitehttps://www.coreychem.com/

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