845264-92-8

Name	Atacicept
CAS	845264-92-8

Synonyms

ATACICEPT Unii-K3D9A0icq3 Research Grade Atacicept (DHB34103)

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Chemical Properties

form	Liquid
color	Colorless to light yellow

Hazard Information

Uses

Atacicept (TACI-Ig) is a is a recombinant fusion protein containing the extracellular, ligand-binding portion of the TACI receptor and the Fc portion of human IgG. Atacicept inhibits B cell stimulation by binding to B lymphocyte stimulator and a proliferation-inducing ligand. Atacicept can be used in research of B-cell autoimmune disease[1][2].

in vivo

Atacicept (TACI-Ig; 100 μg; i.p.; three times of week for 14 days; BALB/c mice) reduces mature B-cell counts and serum antibody levels in normal mice^[1].
Atacicept (TACI-Ig) inhibits the progression of disease and autoantibody titers in a mouse model of collagen-induced arthritis (CIA)^[1].

Animal Model:	Male DBA/1 mice with CIA models^[1]
Dosage:	100 μg
Administration:	intraperitoneal injection; three times of week for 21 days
Result:	Increased serum titers of anti-collagen Abs and few overt signs of disease.

Animal Model:	BALB/c mice^[1]
Dosage:	100 μg
Administration:	intraperitoneal injection; three times of week for 14 days
Result:	Reduced mature B cell populations but had little effect on other cell lineages. Blocked the development of B cells at the transition from T1 to T2 and the development of MZ B cells in the spleen. Decerased the serum levels of IgM about 2.3-fold.

References

[1] Gross JA, et, al. TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease. impaired B cell maturation in mice lacking BLyS. Immunity. 2001 Aug;15(2):289-302. DOI:10.1016/s1074-7613(01)00183-2
[2] Gross JA, et, al. TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease. Nature. 2000 Apr 27;404(6781):995-9. DOI:10.1038/35010115

Supplier

Wuhan Chemstan Biotechnology Co., Ltd.

Telephone027-65317797 15926423062

Websitehttp://www.chemstan.com/

Biolab Reagents

Telephone18108604356 18108604356

Websitehttps://www.biolabreagent.com/

Atagenix Laboratories

Telephone027-87008169 17762441161

Websitehttps://www.abinscience.com/

AntibodySystem Laboratories SAS

Telephone 33175446423

Websitehttp://www.antibodysystem.com

Cell Sciences

Telephone 9785721070

Websitehttp://www.cellsciences.com

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