AJM 290 is a Trx-1 inhibitor. AJM 290 is an inhibitor of the HIF-1α COOH-terminal transactivation domain, and blocks HIF-1 binding to DNA[1].
References
[1] Martin AR,et al. Hypoxia inducible factor down-regulation, cancer and cancer stem cells (CSCs): ongoing success stories. Medchemcomm. 2016 Oct 19;8(1):21-52. DOI:10.1039/c6md00432f