839699-72-8

SirtAct (839699-72-8) is a Sirt1 activator (233% at 10 μM)1 Suppresses TNFα release from THP-1 cells and stimulates adipogenesis in 3T3L1 cells.1 SIRT1 stimulation by SirtAct leads to decreased tissue factor mediated thrombogenicity in mice.2 SirtAct inhibits NFκB activation and reduces inflammatory cytokine production in lamina propria mononuclear cells from IBD patients.3 Prevents and cures experimental colitis in a mouse model.3

SIRT1 Activator 3 is a SIRT1 activator which also inhibits TNF-α.

ChEBI: CAY10591 is a quinoxaline derivative.

1) Nayagam et al. (2006), SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin sensitizing agents; J. Biomol. Screen., 11 959 2) Barbieri et al. (2012), Cyclooxygenase-2-derived prostacyclin regulates arterial thrombus formation by suppressing tissue factor in a sirtuin-1-dependent-manner; Circulation, 126 1373 3) Caruso et al. (2014), Defective expression of SIRT1 contributes to sustain inflammatory pathways in the gut; Mucosal Immunol., May 21 Epub.