Production Methods
The commercial scale manufacturing process of fosmethilan is not available in open literature. However, based on its structure its industrial synthesis would have followed the standard organophosphorus pesticide route used for phosphorodithioate insecticides of the 1970s–1980s: preparation of the anilide intermediate (from 2 chloroaniline and a butanoyl chloride), synthesis of the dimethoxyphosphinothioyl component, and final S alkylation or thiophosphorylation to assemble the phosphorodithioate–anilide structure.
