83729-01-5

Salvinorin A (Item No. 11487) is an analytical reference material categorized as a diterpene. It is a hallucinogen derived from S. divinorum that has been used in the traditional spiritual practices of the Mazatec Indians and as a recreational drug. This product is intended for research and forensic applications.

In traditional medicine, the leaves are used for divination and for treatment of anemia and excretory functions.

Salvinorin A is a hallucinogenic derived from the S. divinorum plant used in traditional spiritual practices of the Mazatec Indians and now gaining popularity as a recreational drug. Unlike other hallucinogens, which mediate their effects through serotonin 5-HT2A receptors, salvinorin A is a potent, selective κ-opioid receptor agonist (Ki = 2.4 nM; EC50 = 1.8 nM). This product is intended for forensic and research applications.In traditional medicine, the leaves are used for divination and for treatment of anemia and excretory functions.

Salvinorin A is a potent and selective kappa-opioid receptor agonist. Salvinorin A has been reported to be brain-penetrant and displays psychoactive properties; hallucinogen.

ChEBI: A natural product found in Salvia divinorum.

Potent naturally occuring non-nitrogenous κ -opioid selective agonist that displays high affinity at both native (K i = 4.3 nM) and cloned (K i = 16 nM) κ -opioid receptors. Also exhibits allosteric modulation of μ -opioid receptor binding. Reported to be brain-penetrant and displays psychoactive properties.

Salvinorin A is a potent, non-nitrogenous κ opioid selective receptor agonist. Salvinorin A is isolated from Salvia divinorum. Salvinorin A displays high affinity at both native (Ki=4.3 nm) and cloned (Ki=16 nm) κ -opioid receptors. Preliminary studies suggest that Salvanorin A is chemically unique among the psychtropic drugs and does not bind to any known receptor.

Desiccate at -20°C

[1] BRYAN L ROTH. Salvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2002, 99 1: 11934-11939. DOI: 10.1073/pnas.182234399
[2] WAYNE W. HARDING. Salvinicins A (I) and B (II), New Neoclerodane Diterpenes from Salvia divinorum.[J]. ChemInform, 2005, 36 47. DOI: 10.1002/chin.200547181
[3] KENJI TSUJIKAWA . Determination of salvinorin A and salvinorin B in Salvia divinorum-related products circulated in Japan[J]. Forensic science international, 2008, 180 2: Pages 105-109. DOI: 10.1016/j.forsciint.2008.07.008
[4] THOMAS A. MUNRO . Standard protecting groups create potent and selective κ opioids: Salvinorin B alkoxymethyl ethers[J]. Bioorganic & Medicinal Chemistry, 2008, 16 3: Pages 1279-1286. DOI: 10.1016/j.bmc.2007.10.067
[5] NICHOLAS J MALCOLM. Mu-opioid receptor selective superagonists produce prolonged respiratory depression.[J]. iScience, 2023, 26 7: 107121. DOI: 10.1016/j.isci.2023.107121