83-98-7

Norflex,Riker,US,1959

Relaxant (skeletal muscle); antihistaminic.

ChEBI: A tertiary amino compound which is the phenyl-o-tolylmethyl ether of 2-(dimethylamino)ethanol.

As described in US Patent 2,567,351, o-methylbenzhydryl bromide is added slowly to β-dimethylaminoethanol at refluxing temperature. After the addition has been completed the mixture is refluxed and stirred for an additional 16 hours. The mixture is cooled and the bottom layer consisting of the crude hydrobromide salt of β-dimethylaminoethanol is drawn off. The excess amino alcohol is distilled from the upper layer in vacuo and the residue is reacted with citric acid.

Norflex (3M Pharmaceuticals).

Muscle relaxant

This muscle relaxant and antihistaminic agent (FWfree-base = 269.39 g/mol; CAS 83-98-7) is both a muscarinic and histamine H1 receptor antagonist that also inhibits some cytochrome P450 systems. Classified as an anticholinergic drug (with 58% as potent as atropine) and an ethanolamine- class antihistamine, it also inhibits the noradrenergic transporter and NMDA receptor ion channel (Ki ≈ 6 μM). Commercially available as either the hydrochloride or citrate salt, orphenadrines used to relieve pain of muscle injuries, such as strains and sprains. Target (s) : aldehyde oxidase ; CYP1A2; CYP2A6; CYP3A4; CYP2B; CYP2B6 ; CYP2C9; CYP2C19; CYP2D6; histamine H1 receptor ; N-methyl-D-aspartate (NMDA) receptor; muscarinic receptor ; noradrenaline reuptake.