819048-44-7

LY2112688 is a beta-melanocyte-stimulating hormone (β-MSH)-derived peptide th at acts as a high-affinitypotent and selective melanocortin receptor 4 (MC-4MC-4RMC4-RMC4R) agonist (human/r at MC-4 Ki = 0.55/0.39 nM; human MC-1/3/5 Ki = 16.78/56.79/>500 nM). LY2112688 selectively induces MC-4-mediated cAMP release (MC-4/3 EC50 = 0.25 nM/1.61 nMMC-4/3 Emax = 94.5%/84.1% of NDP-α-MSH Emax using HEK293 expressing respective human receptors) and exhibits in vivo efficacy in reducing daily food intake and promoting weight loss among diet-induced obese rats (75 & 299 nmol/kg/day s.c.).