Uses
MCP-1 has been used to induce chemotaxis in mice macrophages.', 'MMP-3 human has been used to develop a simple and sensitive electrogenerated chemiluminescence (electrochemiluminescence (ECL)) peptide-based bioassay for the detection of matrix metalloproteinases releasing from living cells.
Biological Activity
Matrix metallopeptidase 3 (MMP3) has a broad substrate specificity and is capable of degrading fibronectinlaminincollagens IIIIVIXand Xand cartilage proteoglycans. It participates in wound repairprogression of atherosclerosistissue remodeling and tumor initiation. MMP3 variants can be associated with hypertrophy of interventricular septum or hypertrophic cardiomyopathy.''The gene JEalso referred to as MCP-1 (monocyte chemoattractant protein-1)encodes a secreted chemokine th at functions as a chemoattractant for monocytes and may activate their anti-tumor properties. This protein may serve as a potential therapeutic anticancer agent.
