794544-99-3

Name	2-Pyridinecarboxamide, N-(2,4-dichlorophenyl)-
CAS	794544-99-3
Molecular Formula	C12H8Cl2N2O
Molecular Weight	267.11
MOL File	794544-99-3.mol

Synonyms

TAS4 TAS-4 TAS 4 2-Pyridinecarboxamide, N-(2,4-dichlorophenyl)-

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Chemical Properties

Boiling point	318.1±37.0 °C(Predicted)
density	1.440±0.06 g/cm3(Predicted)
pka	10.10±0.70(Predicted)

Hazard Information

Description

TAS-4 is a metabotropic glutamate receptor 4-positive allosteric modulator.

Uses

TAS-4 is a potent and selective mGluR4 positive allosteric modulator with significant anti-Parkinson's disease activity. TAS-4 is able to show efficacy when used alone or in combination with l-DOPA. TAS-4 is able to reverse haloperidol-induced spasticity when administered alone. TAS-4 enhances the contralateral rotation behavior induced by l-DOPA in a dose-dependent manner. TAS-4 combined with low-dose l-DOPA shows anti-Parkinson's effects similar to full-dose l-DOPA without exacerbating abnormal motor side effects[1].

References

[1] Therapeutic potential of metabotropic glutamate receptor 4-positive allosteric modulator TAS-4 in rodent models of movement disorders DOI:10.1016/j.jns.2014.07.008

Supplier

Jinan Jiuli Biotechnology Co. , Ltd.

Telephone 15865264761

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList89365/0_EN.htm

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

Shaoguan Qicheng Biotechnology Co., Ltd

Telephone 18122215013

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1488808/0_EN.htm

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