794466-43-6

PBP10 is a cell permeable and selective gelsolin-derived peptide inhibitor of formyl peptide receptor 2 (FPR2) over FPR1[1]. PBP10 is a 10-AA peptide with rhodamine conjugated at its N terminus, exerts bactericidal activity against gram-positive and gram-negative bacteria and limits microbial-induced inflammatory effects[2].

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[1] C C Cunningham, et al.Cell permeant polyphosphoinositide-binding peptides that block cell motility and actin assembly. J Biol Chem DOI:10.1074/jbc.M105289200
[2] Ewelina Piktel, et al. Inhibition of inflammatory response in human keratinocytes by magnetic nanoparticles functionalized with PBP10 peptide derived from the PIP2-binding site of human plasma gelsolin. J Nanobiotechnology. 2019 Feb 2;17(1):22. DOI:10.1186/s12951-019-0455-5