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79183-19-0

Supplier Related Products Identification Chemical Properties Safety Data Hazard Information

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Identification

Name
1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE
CAS
79183-19-0
Synonyms
CS-572
MDK83190
APOPTOSIS ACTIVATOR 2
APOPTOSIS ACTIVATOR II
Apoptosis Activator 2, >=98%
1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE
1-[(3,4-DICHLOROPHENYL)METHYL]-1H-INDOLE-2,3-DIONE
1H-Indole-2,3-dione, 1-[(3,4-dichlorophenyl)methyl]-
1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE USP/EP/BP
1-[(3,4-dichlorophenyl)methyl]-2,3-dihydro-1H-indole-2,3-dione
Apoptosis Activator 2, 97%, a cytochrome c caspase activator and apoptosis inducer
EINECS(EC#)
200-256-5
Molecular Formula
C15H9Cl2NO2
MDL Number
MFCD00141556
MOL File
79183-19-0.mol
Molecular Weight
306.14

Chemical Properties

Boiling point 
470.6±55.0 °C(Predicted)
density 
1.494
Fp 
238.4℃
storage temp. 
Store at RT
form 
Orange to red solid.
pka
-2.69±0.20(Predicted)
Sensitive 
Light Sensitive

Safety Data

Safety Statements 
24/25
RIDADR 
3077
HS Code 
29145090

Hazard Information

Uses
Apoptosis Activator 2 activates caspases in a cytochrome c-dependent manner and induces apoptosis in tumor cells.
Biological Activity
Apoptosis activator; promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumor cells (IC 50 = 4-9 μ M for leukaemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC 50 > 40 μ M).
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