78782-99-7

Calcitriol-d6 is intended for us as an internal standard for the quantification of calcitriol by GC- or LC-MS. Calcitriol is synthesized from 7-dehydro cholesterol in humans via a non-enzymatic photochemical reaction with 290-310 nm UV light in the skin. Hydroxylation of the resulting cholecalciferol in the liver produces 25-hydroxy vitamin D₃, the principal circulating form of vitamin D. A second, tightly regulated hydroxylation in the kidney produces calcitriol. Plasma calcitriol levels range from 10-70 pg/ml and are influenced by numerous dietary and hormonal factors. The main physiologic effects of calcitriol are to increase the absorption of calcium at the level of the intestinal epithelium, and to increase the mineralization of bone via the direct stimulation of osteoblasts.

Off-White to Pale Yellow Solid

The biologically active form of vitamin D3. Calcium regulator; vitamin (antirachitic); antihyperparathyroid; antineoplastic; antipsoriatic

1α,25-Dihydroxyvitamin D3?[1,25(OH)₂D₃], also known as calcitriol, plays a role in calcium and phosphate metabolism in humans. It also regulates insulin secretion and induces cellular differentiation.
1α,25-Dihydroxyvitamin D3-26,26,26,27,27,27-d₆?is a deuterated vitamin D3 wherein C-26 and C-27 carbon methyl protons are replaced by deuterium.

[1] D. E. M. LAWSON. Identification of 1,25-Dihydroxycholecalciferol, a New Kidney Hormone controlling Calcium Metabolism[J]. Nature, 1971, 230 5291: 228-230. DOI: 10.1038/230228a0
[2] M R HAUSSLER. Biological activity of 1alpha-hydroxycholecalciferol, a synthetic analog of the hormonal form of vitamin D3.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1973, 70 8: 2248-2252. DOI: 10.1073/pnas.70.8.2248
[3] L. BINDERUP . 20-EPI-vitamin D3 analogues: A novel class of potent regulators of cell growth and immune responses[J]. Biochemical pharmacology, 1991, 42 8: Pages 1569-1575. DOI: 10.1016/0006-2952(91)90426-6
[4] ANTONIO CANALEJO. The in vitro effect of calcitriol on parathyroid cell proliferation and apoptosis.[J]. Journal of The American Society of Nephrology, 2000, 11 10: 1865-1872. DOI: 10.1681/asn.v11101865