78351-75-4

MY-5445 is a selective inhibitor of the cyclic GMP (cGMP) phosphodiesterase, PDE5, with a K_i value of 1.3 μM. It inhibits calcium- and cAMP-selective PDEs with K_i values of >1,000 and 915 μM, respectively. MY-5445 has been shown to relax intact strips of rat aorta with an EC₅₀ value of 4 μM.

Selective inhibitor of cGMP-specific phosphodiesterase (PDE V, IC50=0.6μM).

ChEBI: N-(3-chlorophenyl)-4-phenyl-1-phthalazinamine is a ring assembly and a member of pyridazines.

Specific inhibitor of cyclic GMP phosphodiesterase, selective for PDE5 (IC 50 = 0.5 μ M).