Acanthifolicin is an okadaic acid derivative that has been shown top inhibit protein phosphatase 1 with an IC50= 20 nM (similar to that of okadaic acid at 19 nM).
Uses
Acanthifolicin, a derivative of Okadaic acid (HY-N6785), is a protein phosphatase inhibitor. Acanthifolicin inhibits protein phosphatase-1 (PP1) and PP2 with IC50 values of 20 nM and 1 nM, respectively[1].
Definition
ChEBI: Acanthifolicin is a ketal.
References
[1] Holmes CF, et al. Inhibition of protein phosphatases-1 and -2A with acanthifolicin. Comparison with diarrhetic shellfish toxins and identification of a region on okadaic acid important for phosphatase inhibition. FEBS Lett. 1990 Sep 17;270(1-2):216-8. DOI:10.1016/0014-5793(90)81271-o
