ChemicalBook CAS DataBase List 77128-69-9

77128-69-9

Name	PYR-GLN-PHE-N-ME-PHE-SAR-LEU-MET-NH2
CAS	77128-69-9
Molecular Formula	C43H61N9O9S
MDL Number	MFCD00133835
Molecular Weight	880.06
MOL File	77128-69-9.mol

Synonyms

DiMe-C7 [pGlu5,MePhe8,Sar9]substance P(5-11) PYR-GLN-PHE-N-ME-PHE-SAR-LEU-MET-NH2 GLP-GLN-PHE-(NME)PHE-SAR-LEU-MET-NH2 [GLP5,(ME)PHE8,SAR9] SUBSTANCE P (5-11) (PYR5,N-ME-PHE8,SAR9)-SUBSTANCE P (5-11) PGLU-GLN-PHE-N-METHYL-PHE-SAR-LEU-MET-NH2 PGLU5,MEPHE8,SAR9-SUBSTANCE P FRAGMENT*5 -11 substance P (5-11), pGlu(5)-MePhe(8)-MeGly(9)- SUBSTANCE P (PGLU5,MEPHE8,SAR9)-*FRAGMEN T 5-11 Substance P, fragment 5-11, [pGlu5, MePhe8, Sar9] [pglu5, n-me-phe8, sar9]-substance p fragment 5-11 SUBSTANCE P [PGLU5, N-ME-PHE8, SAR9]-FRAGMENT 5-11 pGlu-L-Glu(NH2)-L-Phe-N-Methyl-L-Phe-Sar-L-Leu-L-Met-NH2 5-Oxo-L-Pro-L-Gln-L-Phe-N-methyl-L-Phe-N-methyl-Gly-L-Leu-L-Met-NH2 (Pyr 5,N-Me-Phe8, Sar 9)-Substance P (5-11) Pyr-Gln-Phe-N-Me-Phe-Sar-Leu-Met-NH2 L-Methioninamide, 5-oxo-L-prolyl-L-glutaminyl-L-phenylalanyl-N-methyl-L-phenylalanyl-N-methylglycyl-L-leucyl- (9CI)

Chemical Properties

Boiling point	1291.2±65.0 °C(Predicted)
density	1.257±0.06 g/cm3(Predicted)
storage temp.	−20°C
form	Solid
pka	13.13±0.20(Predicted)
color	White to off-white
Sequence	pGlu-Gln-Phe-N-Methyl-Phe-Sar-Leu-Met-NH2

Safety Data

WGK Germany

Hazard Information

Uses

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of addictive agent-seeking behavior in rats[1][2][3].

in vivo

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (2 μg/side; inject into the ventral tegmental area; single) exhibits selective activation of mesolimbic and mesocortical dopamine metabolism in rat brain^[1].
[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (0.5, 1.5, 3 μg/side; inject into the ventral tegmental area; single) increases motor activity and induces recovery of addictive agent-seeking behavior in rats^[2].

Animal Model:	Male Sprague-Dawley rats (300-350 g)^[1].
Dosage:	2 μg/side
Administration:	Inject into the ventral tegmental area; single
Result:	Selectively activated mesolimbic and mesocortical dopamine metabolism.

Animal Model:	Male Wistar rats (300-350 g)^[2].
Dosage:	0.5, 1.5, 3 μg/side
Administration:	Inject into the ventral tegmental area; single
Result:	Significantly increased locomotor activity when at 3 μg/side.

References

[1] Elliott PJ, et al. Selective activation of mesolimbic and mesocortical dopamine metabolism in rat brain by infusion of a stable substance P analogue into the ventral tegmental area. Brain Res. 1986 Jan 15;363(1):145-7. DOI:10.1016/0006-8993(86)90667-0
[2] Eison AS, et al. Substance P analog, DiMe-C7: evidence for stability in rat brain and prolonged central actions. Science. 1982 Jan 8;215(4529):188-90. DOI:10.1126/science.6171884
[3] Placenza FM, et al. Infusion of the substance P analogue, DiMe-C7, into the ventral tegmental area induces reinstatement of cocaine-seeking behaviour in rats. Psychopharmacology (Berl). 2004 Dec;177(1-2):111-20. DOI:10.1007/s00213-004-1912-9

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