ChEBI: A symmetrical oxalamide-based bis-quaternary ammonium ion having ethyl and 2-chlorobenzyl groups attached to the nitrogens.
Brand name
Mytelase (Sanofi Aventis).
Pharmacology
The pharmacological properties of ambenonium are similar to neostigmine and pyridostigmine, and it works by reversible inactivation of cholinesterase.
Synthesis
Ambenonium, [oxalyl-bis-(iminoethylen)]-bis-[ortho-(chlorobenzyl)
diethylammonium] chloride (13.2.15), is made by reacting diethyloxalate with two moles of
N,N-diethylethylendiamine, forming oxalyl-bis-(iminoethylen)-bis-N,N-diethylamine
(13.2.14), which is alkylated by two moles of 2-chlorobenzylchloride, giving ambenonium
(13.2.15) [46¨C48].
