76330-73-9

Name	ketanserinol
CAS	76330-73-9
MOL File	76330-73-9.mol

Synonyms

R-46742 ketanserinol Reduced ketanserin 3-[2-[4-[(4-Fluorophenylcarbonyl)(hydroxy)methyl]piperidin-1-yl]ethyl]-2,4(1H,3H)-quinazolinedione

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Chemical Properties

form	Solid
color	White to off-white

Hazard Information

Description

Ketanserinol is the metabolite of ketanserin, a hypotensive drug with 5-HT2 receptor antagonism. Ketanserin is used to reverse pulmonary hypertension caused by protamine.

Uses

Ketanserinol (R 46742) is a metabolite of Ketanserin (HY-10562). Ketanserinol is a competitive antagonist of the effects of 5-HT (HY-B1473A) in both arteries. The KB values are 6.5 for large coronary arteries and 6.4 for pulmonary arteries[1].

References

[1] Frenken M, et al. Interaction of ketanserin and its metabolite ketanserinol with 5HT2 receptors in pulmonary and coronary arteries of calf. Naunyn Schmiedebergs Arch Pharmacol. 1984 Jul;326(4):334-9. DOI:10.1007/BF00501438

Spectrum Detail

ketanserinol(76330-73-9)¹HNMR

Supplier

Shanghai Haohong Scientific Co., Ltd.

Telephone400-8210725 4008210725

Websitehttps://www.leyan.com/

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

Guangzhou Ruidi Biotechnology Co., Ltd.

Telephone020-82099279 18988941402

Websitehttp://www.ubiochem.com/

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