76166-55-7

Benafentrine dimaleate is a phosphodiesterase (PDE) 3/4 inhibitors and platelet activating factor receptor (PAFR) antagonists potentially for the treatment asthma.

Benafentrine maleate is a platelet activating factor receptor (PAFR) antagonist and a PDE 4 inhibitor[1].

[1] Kelly JJ, et al. Phosphodiesterase 4 in macrophages: relationship between cAMP accumulation, suppression of cAMP hydrolysis and inhibition of [3H]R-(-)-rolipram binding by selective inhibitors. Biochem J. 1996 Sep 1;318 ( Pt 2)(Pt 2):425-36. DOI:10.1042/bj3180425