75104-92-6

In a sealed reaction tube, 6-bromo-2-chlorobenzo[d]thiazole (701) (0.5 g, 2.0 mmol) was dissolved in methylamine solution (20 mL), and the resulting mixture was stirred and reacted at 60 °C overnight. Upon completion of the reaction, the mixture was cooled to room temperature, concentrated under reduced pressure to remove the solvent and quenched by the addition of water (20 mL). The precipitated solid was collected by filtration to afford the target product 6-bromo-N-methylbenzo[d]thiazol-2-amine (702) (0.43 g, 87.9% yield). The product was analyzed by ESI-MS and showed (M + H)+ m/z: 242.8.

[1] Patent: US2015/225407, 2015, A1. Location in patent: Paragraph 0416
[2] Recueil des Travaux Chimiques des Pays-Bas, 1934, vol. 53, p. 1
[3] Patent: WO2017/46739, 2017, A1. Location in patent: Page/Page column 50