74578-38-4

Name	1-UFT protocol
CAS	74578-38-4
Molecular Formula	C12H13FN4O5
MDL Number	MFCD01750796
Molecular Weight	312.254
MOL File	74578-38-4.mol

Synonyms

UFT Ufur UFT-E Uftoral Youfuding BMS-200604 1-UFT protocol Tegafur uracil Tegafur/Uracil Tegafur·uracil Tegafur-Uracil Tegafur-uracil Mixt. Uracil-Futraful Mixt. 5-fluoro-1-(oxolan-2-yl)pyrimidine-2,4-dione:1H-pyrimidine-2,4-dione

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Chemical Properties

form	Solid
color	White to off-white

Hazard Information

Uses

Tegafur-Uracil (UFT; BMS-200604) is an effective oral chemotherapy drug based on fluoropyrimidine. Tegafur-Uracil inhibits thymidylate synthase. Tegafur-Uracil can be used in combination with leucovorin (LV) and polysaccharide K (PSK) for research on solid tumors[1][2].

in vivo

Tegafur-Uracil (60 mg/kg, orally, once a day for 9 days) combined with folinic acid and protein-bound polysaccharides enhances the anti-tumor activity in mice^[2].

Animal Model:	BLAB/c mice^[2]
Dosage:	60 mg/kg; daily; 9 days
Administration:	Oral
Result:	Reduced tumor size.

References

[1] Casado E, et al. UFT (tegafur-uracil) in rectal cancer. Ann Oncol. 2008;19(8):1371-1378. DOI:10.1093/annonc/mdn067
[2] Ryoji Katoh, et al. Enhancement of antitumor effect of tegafur/uracil (UFT) plus leucovorin by combined treatment with protein-bound polysaccharide, PSK, in mouse models. Cell Mol Immunol. 2007 Aug;4(4):295-9. PMID:17764620

Supplier

SPIRO PHARMA

Telephone

Websitehttp://www.spiropharma.com.cn

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

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17902-23-7 57610-22-7

1397179-21-3 110522-47-9

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