ChemicalBook CAS DataBase List 74389-68-7

74389-68-7

Name	Platelet Activating Factor-16
CAS	74389-68-7
Molecular Formula	C26H54NO7P
MDL Number	MFCD00043214
Molecular Weight	523.68
MOL File	74389-68-7.mol

Chemical Properties

Melting point	247 °C
storage temp.	-20°C
solubility	Soluble in H2O or ethanol
form	lyophilized powder
color	White to off-white
Water Solubility	Soluble to 100 mM in water
BRN	3574588
InChI	1S/C26H54NO7P.H2O/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21-31-23-26(34-25(2)28)24-33-35(29,30)32-22-20-27(3,4)5;/h26H,6-24H2,1-5H3;1H2/t26-;/m1./s1
InChIKey	HFMSDOHEENWULV-UFTMZEDQSA-N
SMILES	O.CCCCCCCCCCCCCCCCOC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(C)=O

Safety Data

Hazard Codes	Xn
Risk Statements	22-38-40-48/20/22 less more
Safety Statements	36/37-24/25-22 less more
RIDADR	UN 1888 6.1/PG 3
WGK Germany	3
RTECS	EC6060000
F	10-21
Storage Class	11 - Combustible Solids

Hazard Information

Uses

C16-02:0 PC or 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine may be used as a substrate in enzymatic lipoprotein-associated phospholipase A2 (Lp-PLA2) activity assay. It may also be used to study its physicochemical properties and its interaction with peptides derived from the C-terminal domains of human apolipoprotein E.

Uses

PAF (C16) (cas# 74389-68-7) is a blood platelet-activating factor, used to study human airway smooth muscle cell line.

Definition

ChEBI: A 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine betaine which has hexadecyl as the alkyl group. PAF is a potent phospholipid activator and mediator of many leukocyte functions, including platelet aggregation, inflammation, and anaphylaxis.

General Description

C16-02:0 PC, also known as 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (C16 PAF) (acetyl PAF), is a platelet-activating factor (PAF). Acetyl PAF is present in the body and it contains ether-linked hexadecyl chain at the sn-1 position and an acetyl group at the sn-2 position.

Biological Activity

Endogenous platelet-activating factor (PAF) and ligand for PAF receptors. Produced by inflammatory cells and a potent chemoattractant for polymorphonuclear neutrophils. Induces increased vascular permeability.

Biochem/physiol Actions

Platelet-activating factor (PAF) is a pro-inflammatory agent that exhibits variety of biological and pharmacological effects. It plays a major role in initiation and progression of atherosclerosis. PAF acts as a potential biomarker for coronary artery diseases. It yields LysoPAF (1-O-alkyl-2-hydroxy-sn-glycero-3-phosphocholine) on hydrolysis by platelet-activating factor-acetylhydrolase.

storage

Store at -20°C

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