73101-74-3

The general procedure for the synthesis of 2-bromomethylbenzoxazole from 2-methylbenzoxazole was as follows: 2-methylbenzoxazole (665 mg, 5 mmol) was dissolved in carbon tetrachloride (16 mL) under stirring conditions, followed by the addition of N-bromosuccinimide (890 mg, 5 mmol) and azobis(isobutyronitrile) (188 mg, 1.15 mmol) in sequence. The reaction mixture was stirred at 0 °C and then heated to reflux for 12 hours. After completion of the reaction, it was cooled to room temperature, filtered to remove insoluble material and the filtrate was concentrated. Finally, the residue was purified by column chromatography to afford 2-bromomethylbenzoxazole as a light yellow oil (471 mg, 45% yield).

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