730960-98-2

NSC 15520 is an inhibitor of replication protein A 70 (RPA70) dsDNA binding.¹ It selectively inhibits dsDNA over ssDNA binding to RPA70 when used at concentrations ranging from 25 to 400 μM. NSC 15520 also inhibits the protein-protein interaction between the cell cycle checkpoint control proteins p53 or Rad9 and RPA70.

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1. Glanzer, J.G., Liu, S., and Oakley, G.G. Small molecule inhibitor of the RPA70 N-terminal protein interaction domain discovered using in silico and in vitro methods Bioorg. Med. Chem. 19(8),2589-2595(2011).