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L-644,698 is a novel selective human prostanoid DP receptor agonist.

L-644698 is a potent and selective human recombinant prostaglandin D2 (PGD2) receptor (hDP) agonist with Ki values of 0.9, 267, 3730, 9280 nM for hDP, hEP2, hEP3, hEP4, respectively. L-644698 induces cyclic AMP production with an EC50 value of 0.5 nM[1].

hDP receptor: 0.9 nM (Ki); hEP2: 267 nM (Ki); hEP3: 3730 nM (Ki); hEP4: 9280 nM (Ki)

[1] Wright DH, et al. Characterization of the recombinant human prostanoid DP receptor and identification of L-644,698, a novel selective DP agonist. Br J Pharmacol. 1998 Apr;123(7):1317-24. DOI:10.1038/sj.bjp.0701708