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Thielavin B is a fungal metabolite that contains O-substituted salicylic acid. It inhibits cyclooxygenase, blocking both the conversion of arachidonic acid to Prostaglandin H₂ (PGH₂) and the conversion of PGH₂ to PGE₂ (, IC₅₀s = 40 and 9 μM, respectively). Thielavin B also inhibits the reverse transcriptase of avian myeloblastosis virus, bacterial transglycosylases, and telomerase activity.

Thielavin B is a fungal metabolite closely related to thielavin A but reported to have a slightly different biochemical profile. Thielavins inhibit glucose-6-phosphatase. Thielavin B is a potent inhibitor of phospholipase C, and inhibits peptidoglycan formation and prostaglandin biosynthesis.

Thielavin B is a fungal metabolite of?Thielavia terricola that contains O-substituted salicylic acid. It is an inhibitor of viral reverse transcriptase and telomerase.

Natural product derived from fungal source.

[1] N MANI. Screening systems for detecting inhibitors of cell wall transglycosylation in Enterococcus. Cell wall transglycosylation inhibitors in Enterococcus.[J]. Journal of Antibiotics, 1998, 51 5: 471-479. DOI: 10.7164/antibiotics.51.471
[2] KEN-ICHI TOGASHI. Inhibition of Telomerase Activity by Fungus Metabolites, CRM646-A and Thielavin B[J]. Bioscience, Biotechnology, and Biochemistry, 2001, 65 1: 651-653. DOI: 10.1271/bbb.65.651