71774-13-5

(S)-Adenosine, cyclic 3'',5''-(hydrogenphosphorothioate) triethylammonium is an activator of PKA.

ChEBI: (Sp)-cAMPS is a nucleoside 3',5'-cyclic phosphorothioate having adenine as the nucleobase (the Sp-stereoisomer). It has a role as a protein kinase agonist. It is a member of purines and a nucleoside 3',5'-cyclic phosphorothioate. It is functionally related to a 3',5'-cyclic AMP.

Cell-permeable cAMP analog that activates cAMP receptor proteins such as PKA and cAMP-regulated guanine nucleotide exchange factor.

PKA I; PKA II; PDE3A: 47.6 μM (Ki); PDE10 GAF domain: 50 μM (EC₅₀)