71636-61-8

Name	(+/-)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE
CAS	71636-61-8
Molecular Formula	C16H17BrClNO2
MDL Number	MFCD00153782
Molecular Weight	370.67
MOL File	71636-61-8.mol

Synonyms

sk&f81297 (±)-6-Chloro-PB SKF 81297 hydrobromi SKF 81297 HYDROBROMIDE (+/-)-SKF-81297 HYDROBROMIDE (+/-)-6-CHLORO-PB HYDROBROMIDE (+-)-6-CHLORO-PB HYDROBROMIDE (+-)-SKF-8 1297, HCL 2,3,4,5-Tetrahydro-6-chloro-1-phenyl-1H-3-benzazepine-7,8-diol 6-Chloro-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol 6-Chloro-2,3,4,5-tetrahydro-1-phenyl-1H-3-benzazepine-7,8-diol 6-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol 1H-3-Benzazepine-7,8-diol, 6-chloro-2,3,4,5-tetrahydro-1-phenyl- 6-Chloro-2,3,4,5-tetrahydro-1-phenyl-1H-3-benzazepinehydrobromide 6-CHLORO-2,3,4,5-TETRAHYDRO-1-PHENYL-1H-3-BENZAZEPINE-7,8-DIOL HYDROBROMIDE (+/-)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE (±)-SKF-81297 hydrobromide, (±)-6-Chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

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Chemical Properties

storage temp.	Desiccate at +4°C
solubility	H₂O: 1.7 mg/mL
form	solid
color	gray

Safety Data

Hazard Codes	Xi
Risk Statements	36/37/38 less more
Safety Statements	22-26-36 less more
WGK Germany	3

Hazard Information

Uses

(±)-6-Chloro-PB hydrobromide has been used as a dopamine D1 receptor (Drd1a) agonist to study the role of the drd1a-dopamine receptor inactivation of extracellular signal?regulated protein kinase 1/2 (ERK1/2) in the wild-type and striatum of dopamine-depleted mice. It has also been used as a Drd1a agonist to identify the contribution of D1 (D1R)-like dopamine receptor signaling on learning and memory in Barnes maze in rats.

Definition

ChEBI:9-chloro-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol is a benzazepine.

Biological Activity

Dopamine D 1 -like receptor agonist. Centrally active following systemic administration in vivo .

Biochem/physiol Actions

(+/-)-6-Chloro-PB HBr is a full D1 dopamine receptor agonist.

Supplier

3B Pharmachem (Wuhan) International Co.,Ltd.

Telephone821-50328103-801 18930552037

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList13285/0.htm

Sigma-Aldrich

Telephone021-61415566 800-8193336

Websitehttps://www.sigmaaldrich.cn

Shanghai Universal Biotech Co.,Ltd

Telephone15921930842 15921930842

Websitehttps://www.univ-bio.com/

TargetMol Chemicals Inc.

Telephone 4008200310

Websitehttps://www.targetmol.cn/

Nantong QuanYi Biotechnology Co., Ltd

Telephone0513-66337626 18051384581

Websitehttps://www.chemhifuture.com/

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