69570-95-2

V-161 is the orally active inhibitor for Na+-V-ATPase with an IC50 of 144 nM. V-161 inhibits Enterococcus hirae and Vancomycin-resistant Enterococcus faecium (VRE) under alkaline condition with MIC of 4 μg/mL and 4 μg/mL. V-161 inhibits colonization of VRE in mouse small intestine[1].

[1] Suzuki K, et al., Na+-V-ATPase inhibitor curbs VRE growth and unveils Na+ pathway structure. Nat Struct Mol Biol. 2024 Nov 21. DOI:10.1038/s41594-024-01419-y