ChemicalBook CAS DataBase List 69430-36-0

69430-36-0

Name	Keratin hydrolyzed
CAS	69430-36-0
EINECS(EC#)	274-001-1
Molecular Formula	C2H2BrClO2
MDL Number	MFCD00131434
Molecular Weight	173.393
MOL File	69430-36-0.mol

Synonyms

CL245 from Wool Cattle hair Keratin&nbsp BCAA(Instant) (5% in Water) Keratin from Wool Proteinhydrolysat HYDROLYZED KERATIN Hydrolysed protein Keratin hydrolyzed Keratin hydrolyzate keratin hydrolysate HYDROLYSED KERATINE keratin hydrolysates KERATIN (5% IN WATER) Keratins, hydrolyzates Keratin hydrolyzed,Soluble Keratin Keratin (partially sulfonated, 5% in Water) Keratins,cattle horn,saponified and neutralized

Chemical Properties

Odor	Characteristic
Cosmetics Ingredients Functions	SKIN CONDITIONING FILM FORMING HAIR CONDITIONING ANTISTATIC HUMECTANT
Cosmetic Ingredient Review (CIR)	Keratin hydrolyzed (69430-36-0)
InChI	InChI=1S/C2H2BrClO2/c3-1(4)2(5)6/h1H,(H,5,6)
InChIKey	GEHJBWKLJVFKPS-UHFFFAOYSA-N
SMILES	C(O)(=O)C(Br)Cl
Uses	hydrolyzed keratin is a processed form of keratin that facilitates its use in skin care formulations. less more
EPA Substance Registry System	Keratins, hydrolyzates(69430-36-0)

Safety Data

TSCA	TSCA listed

Hazard Information

Chemical Properties

Hydrolyzed keratin is a large protein molecule that is broken down after a chemical process in a manner such that it can penetrate the hair cuticle. It is sourced from a larger keratin molecule.Keratin is broken down by splitting its bond with the addition of hydrogen and hydroxide (water). At the end of the chemical process, the keratin is reduced into smaller fragments that the hair can absorb, thanks to its lower molecular weight.

Definition

Hydrolyzed keratin is a compound that can reverse the damage done to keratin. It is found in many hair care products and helps rejuvenate, strengthen, and moisturize the hair. In addition, this protein increases the smoothness of the hair.

Preparation

Keratin hydrolyzed is prepared from chicken feathers by alkaline-enzymatic hydrolysis followed by dialysis purification, or produced from raw feathers using the keratinolytic bacterium Vibrio sp. strain kr2[2][3]. Sheep wool serves as a substrate for producing hydrolysate through optimized alkaline hydrolysis using hybrid response surface methodology with Box-Behnken design[1]. Microbial keratinase hydrolysis yields a product rich in soluble proteins without loss of essential amino acids[2].

benefits

Hydrolyzed protein can repair and condition damaged hair. These protein hydrolysates strengthen hair fibers and reduce hair breakage.Protein hydrolysates are often added to hair coloring products for even color absorption.Hydrolyzed protein protects the hair from the damaging effects of permanent bleaching, waving, and straightening products.It improves the texture and natural structure of the hair and forms a protective coating to shield the strands.

Toxicology

Keratin Hydrolyzed sourced from sheep wool and hoof meal was non-toxic in oral studies in rats (i.e. the LD50 was greater than 40 ml/kg in a 20% solution). Keratin (MW = 8000 Da and 33,000 Da; buffalo horn/hoof source) and Hydrolyzed Keratin (MW = 310 Da; sheep wool source) were non-toxic in intravenous studies in mice.

References

[1]Metomo, F. N. N. N., Tayi, F., Younes, E., Amadine, O., & Zahouily, M. (2024). Production of sheep wool keratin hydrolysate and evaluation of its effectiveness in promoting maize cultivation. Journal of Environmental Management, 366, 121648. https://doi.org/10.1016/j.jenvman.2024.121648
[2]Mokrejš, P., Huťťa, M., Pavlačková, J., & Egner, P. (2017). Preparation of Keratin Hydrolysate from Chicken Feathers and Its Application in Cosmetics. Journal of Visualized Experiments, 129(129). https://doi.org/10.3791/56254
[3]Grazziotin, A., Pimentel, F. A., Sangali, S., de Jong, E. V., & Brandelli, A. (2007). Production of feather protein hydrolysate by keratinolytic bacterium Vibrio sp. kr2. Bioresource Technology, 98(16), 3172–3175. https://doi.org/10.1016/j.biortech.2006.10.034

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Chemical Properties

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Hazard Information

Chemical Properties

Definition

Preparation

benefits

Toxicology

References

Questions And Answer

Description

Referrence

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