[1] Johansson*, L., Fotsch, C., Bartberger, M. D., Castro, V. M., Chen, M., Emery, M., Gustafsson, S., Hale, C., Hickman, D., Homan, E., Jordan, S. R., Komorowski, R., Li, A., McRae, K., Moniz, G., Matsumoto, G., Orihuela, C., Palm, G., Veniant, M., … Zhang, J. (2008). 2-Amino-1,3-thiazol-4(5H)-ones as Potent and Selective 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors: Enzyme−Ligand Co-Crystal Structure and Demonstration of Pharmacodynamic Effects in C57Bl/6 Mice.
Journal of Medicinal Chemistry,
51 10, 2933–2943.
https://doi.org/10.1021/jm701551j